Betulinic acid
Delivery term:The date of payment from buyers deliver within days- Price:
Negotiable
- minimum:
- Total supply:
- Delivery term:
The date of payment from buyers deliver within days
- seat:
Beijing
- Validity to:
Long-term effective
- Last update:
2023-07-23 14:15
- Browse the number:
88
- Xi'an Kintai Biotech Inc. By certification [File Integrity]
-
Contact:
jintaisw(Mr.)
- Email:
- Telephone:
- Phone:
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Area:
Beijing
-
Address:
3rd Floor, Unit 3, Building 16, Zhongnan Hi tech Airport Industrial Port, Airport New City, Xixian New Area, Shaanxi Province, China.
- Website: http://www.kintai-bio.com/ http://jintaisw.zg-boiler.com/
Product details
Betulinic acid widely exists in the plant kingdom, including Araliaceae (Acanthopanax root bark), Betaceae (white birch bark, weeping birch bark, sweet birch bark), rosemary, Yunnan licorice, wild jujube, etc. Both contain a certain amount of Betulonic Acid. Kintai's Betulonic Acid uses betulin as a precursor, which is transformed into Betulonic Acid by microorganisms.
In recent years, scientific research has found that BA is a very valuable natural product. As biological agents, BA and its derivatives have shown great potential in anti-cancer and HIV treatment, play an important role in the body's anti-oxidative damage and immune regulation process, and are a class of promising drug lead compounds. It is of great value for the development of new drugs.
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CAS Number |
472-15-1 |
Molecular Weight |
456.700 |
Density |
1.1±0.1 g/cm3 |
Boiling Point |
550.0±33.0 °C at 760 mmHg |
Molecular Formula |
C30H48O3 |
Melting Point |
295-298 °C (dec.)(lit.) |
Common Name |
Betulinic acid |
Flash Point |
300.5±21.9 °C |
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Product name |
Betulonic Acid |
Extract source |
Birch bark |
Extraction Solvent |
Ethyl alcohol |
Appearance |
White powder |
Solubility |
Soluble in: chloroform, ethanol, acetone, methanol, ether; very slightly soluble in benzene |
Identification |
HPLC |
Ash |
NMT 0.5% |
Heavy metals |
NMT 20 PPM |
Loss On Drying |
NT 5.0% |
Powder size |
80Mesh, NLT90% |
Assay |
Min. 95.0% |
Residual Solvents |
|
- N-hexane |
NMT 290 PPM |
- Methanol |
NMT 3000 PPM |
- Acetone |
NMT 5000 PPM |
- Ethyl Acetate |
NMT 5000 PPM |
- Ethanol |
NMT 5000 PPM |
Pesticide Residues |
|
- Total DDT (Sum of p,p'-DDD,P,P'-DDE,o,p'-DDT and p,p' -DDT) |
NMT 0.05 PPM |
- Aldrin, Endrin, Dieldrin |
NMT 0.01 PPM |
Microbiological Quality (Total viable aerobic count) |
|
- Bacteria, CFU/g, not more than |
NMT 103 |
- Moulds and yeasts, CFU/g, not more than |
NMT 102 |
- E.coli, Salmonella, S. aureus, CFU/g |
Absence |
Storage |
In Tight, Light-resistant and Dry Place. Avoid Direct Sunshine. |
Shelf life |
2 years |
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1)Antioxidant stress activation
BA has a protective effect on normal cells and the body, which is related to antioxidant stress. For example, Betulonic Acid has protective effects on ischemia-reperfusion injury in the brain, kidneys, and heart. BA has protective effects on cerebral ischemia-reperfusion injury in mice through antioxidant stress, anti-nitrogen stress, and increased blood flow.
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2) Anti-inflammatory effect
Most pentacyclic triterpenes have anti-inflammatory activities. Both betulin and Betulonic Acid have mild anti-inflammatory properties at higher concentrations, and their anti-inflammatory properties may depend on their inhibition of protein kinase C, without involving any neurogenic inflammatory mechanisms. There are also studies indicating that its activity is the result of interaction with glucocorticoid receptors.
The anti-inflammatory effect of Betulonic Acid has been verified in vitro and in vivo model systems. Betulonic Acid can inhibit the production of PGE2 and alleviate inflammatory reactions.
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3) Bacteriostatic effect
It has been found that Betulonic Acid has a certain antibacterial effect, which can inhibit a variety of bacteria including Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Staphylococcus epidermidis. However, studies have shown that its antibacterial activity is weak, which may be related to its belonging to lupine pentacyclic triterpenes, its structure is similar to that of hopane pentacyclic triterpenes, and the presence of substances on the bacterial membrane that can biosynthetically synthesize hopane pentacyclic triterpenes. Based on the existing research on the antibacterial ability of Betulonic Acid, its potential as an antibacterial agent is small.
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4) Anti-tumor effect of Betulonic Acid
Betulonic Acid was first found to have extremely strong selective cytotoxicity in melanoma cells. In recent years, it has also been found to have a strong broad-spectrum activity to other tumor cells, such as glioblastoma, neuroblastoma, neuroblastoma, Ewing tumor and other malignant tumors, colon cancer, breast cancer, lung cancer, liver cancer, prostate cancer, kidney cell Ovarian or cervical cancer and leukemia have strong inhibitory effects.
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5) Antiviral effect
Betulonic Acid has prominent antiviral activity, especially HIV activity, and has effective effects on anti-hepatitis C virus, anti-herpes simplex virus, anti-Eico virus, and anti-influenza virus.
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1. Application in cosmetics
(1) Skin whitening effect: low-concentration Betulonic Acid can be used as a skin conditioning aid, and it can be used in combination with ascorbic acid to promote the production of cortical collagen;
(2) Use in hair products can promote hair growth; data on free radical DMBA elimination show that Betulonic Acid has anti-inflammatory and anti-skin allergy effects, and it can reduce skin irritation when used in high SPF sunscreen lotion.
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2. Medicine field
BA is a very valuable natural product. As biological agents, BA and its derivatives have shown great potential in anti-cancer and HIV treatment, play an important role in the body's anti-oxidative damage and immune regulation process, and are a class of promising drug lead compounds. It is of great value for the research and development of new drugs, and the NCI of the American Cancer Institute has included it in the Rapid Research and Development Program (RAID).
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CTFA uses Betulonic Acid as a cosmetic raw material, and it is included in the 2010 edition of the "International Cosmetic Raw Material Standard Chinese Name Catalogue" issued by the China Fragrance Association. Included, there is no report that it is unsafe for external use.
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 |
Moisturizing Lotion |
Soothing Cream |
Antioxidant Serum |
Formulas |
Betulonic Acid 0.5% Hyaluronic Acid 1.0% Glycerin 3.0% Wheat Protein 2.0% Natural Vitamin E 0.1% Rosemary Extract 0.5% Water 88.9% |
Betulonic Acid 0.3% Aloe Vera Extract 3.0% Glycerin 2.0% Pomegranate Seed Oil 5.0% Arnica Extract 1.0% Honey 2.0% Water 86.7% |
Betulonic Acid 0.8% Green Tea Extract 2.0% Natural Vitamin C 5.0% Mangosteen Seed Oil 4.0% Erigeron Extract 1.0% Coenzyme Q10 0.5% Water 86.7% |
 |
The above three reference formulas are all developed based on the anti-oxidation, moisturizing, and anti-aging effects of Betulonic Acid. At the same time, when using Betulonic Acid, it is necessary to pay attention to controlling the dosage and matching other ingredients reasonably to fully exert its efficacy and ensure the safety and stability of the product. |
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Dosage |
The dosage of Betulonic Acid is generally 0.1%~1.0%. In the formulation, it can be used in combination with other natural ingredients such as vitamin E, honey, aloe vera, green tea, licorice, etc. to form creams, lotions, essences, and other products with multiple functions such as maintenance, soothing, moisturizing, and anti-aging. |
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Introduction of three extraction methods of Betulonic Acid
- First, it is extracted and isolated from natural plants. This method consumes a lot of solvents, the yield is low, and the impurities are not easy to separate, so it is rarely used;
- Second, Betulonic Acid was obtained through organic synthesis using betulin as a precursor. This method has been applied in industrial production, and industrial-scale Betulonic Acid can be obtained, which is the main source of Betulonic Acid in the market now;
- Third, use betulin as a precursor to produce Betulonic Acid through microbial conversion. This approach represents a new direction for the future plant extraction industry and is the main advantage of KINTAI in producing this product.
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http://www.kintai-bio.com/
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